BISOPROLOL Concore 10 milligrams
Generic Name: BISOPROLOL
Brand Name: Concore
Dosage Strength: 10 milligrams
Dosage Form: Tablet
WHAT IS THE MEDICINE USED FOR?
(Indication) Treatment of stable chronic moderate to severe heart failure w/ reduced systolic ventricular function.
HOW MUCH AND HOW OFTEN SHOULD YOU USE THIS MEDICINE?
(Dosage) Stable chronic heart failure Patient must be treated at optimal dose w/ ACE inhibitor & diuretic & optionally cardiac glycosides, prior to administration of bisoprolol. Titrate gradually as follows: 1.25 mg once daily for 1 wk then 2.5 mg once daily for a further wk then 3.75 mg once daily for a further wk then 5 mg once daily for the next 4 wk then 7.5 mg once daily for the next 4 wk then 10 mg once daily for the maintenance therapy. HTN & angina pectoris 5 mg once daily, may be increased to 10 mg once daily.
(Contraindications) Acute heart failure or during episodes of heart failure; decompensation requiring IV inotropic therapy; cardiogenic shock; 2nd- or 3rd-degree AV block; sick sinus syndrome; SA block; bradycardia w/ <60 beats/min; hypotension; severe bronchial asthma or severe COPD; late stages of peripheral arterial occlusive disease & Raynaud’s syndrome; untreated pheochromocytoma; metabolic acidosis.
(Precautions) Bronchospasm; DM w/ large fluctuations in blood glucose values; strict fasting; ongoing desensitization therapy; 1st-degree AV block; Prinzmetal’s angina; peripheral arterial occlusive disease; psoriasis; impaired liver/renal function. Pregnancy & lactation.
(Adverse Reactions) Feeling of coldness or numbness in the extremities, nausea, vomiting, diarrhea, constipation. Tiredness, fatigue, dizziness; headache occur at start of treatment but usually disappear after 1-2 wk.
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