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Domperidone is a medication that acts as a dopamine antagonist. It is primarily used to treat gastrointestinal issues by enhancing the motility of the upper gastrointestinal tract and alleviating symptoms such as nausea and vomiting.
Description:
1. Formulation
o Strength: Each film-coated (FC) tablet contains 10 mg of domperidone.
o Formulation: The film-coated tablet is designed to improve the medication's stability, mask any unpleasant taste, and facilitate easier swallowing.
2. Indications
Domperidone is used to treat various conditions related to gastrointestinal motility and nausea, including:
o Nausea and Vomiting: Domperidone is used to relieve nausea and vomiting from various causes, including those induced by other medications or gastrointestinal disorders.
o Gastric Emptying Disorders: It helps in conditions where there is delayed gastric emptying, such as in gastroparesis.
o Functional Dyspepsia: It can be used to relieve symptoms associated with functional dyspepsia, such as fullness, bloating, and discomfort after meals.
3. Age Groups
o Adults: The typical dosage for adults is 10 mg taken up to three times daily before meals. The dosage may be adjusted based on the specific condition and response.
o Elderly: Caution is advised in elderly patients, who may be more sensitive to side effects. Dosage adjustments may be required.
o Children: Domperidone is generally not recommended for children under 12 years of age. The safety and efficacy in pediatric populations have not been well established.
4. Contraindications
Domperidone should be avoided or used with caution in the following conditions:
o Hypersensitivity: Known allergy or hypersensitivity to domperidone or any of its components.
o Severe Hepatic Impairment: Domperidone is contraindicated in patients with severe liver impairment due to the risk of accumulation and adverse effects.
o Prolactin-Secreting Pituitary Tumors (Prolactinomas): Domperidone can increase prolactin levels, which may exacerbate conditions like prolactin-secreting tumors.
o Severe Renal Impairment: Caution is advised in patients with severe renal impairment, and dosage adjustments may be necessary.
o Concurrent Use with Certain Medications: Domperidone should be used cautiously with medications that prolong the QT interval or interact with the drug, such as some antipsychotics and antidepressants.
5. Additional Considerations
o Side Effects: Common side effects may include dry mouth, headache, dizziness, and gastrointestinal disturbances. Serious side effects are rare but may include cardiac arrhythmias.
o Drug Interactions: Domperidone can interact with other medications, particularly those affecting heart rhythm. Always inform your healthcare provider of all medications you are taking.
Domperidone 10 mg FC Tablets should be used according to the healthcare provider's instructions, who will tailor the dosage based on the patient's specific condition and monitor for potential side effects.