Acetylcysteine Sachet 200mg (TGP)-10
Use for its mucolytic activity in respiratory disorders associated with productive cough and in the management of Paracetamol overdosage.
Dosage and Administration:
Acetylcysteine is used for its mucolytic activity in respiratory disorders associated with acute cough. It can be give by nebulisation of 3 to 5mL of 20 % solution or 6 to 10mL of a 10 % solution through a face mask or mouthepiece 3 or 4 times daily. Acetylcysteine has been given by mouth in doses of 200mg two or three times daily as granules or effervescent dissolved in 30mL of water. Children aged 1 month to 2 years may be given 100mg twice daily, and those aged 2 to 7 years 200mg twice daily. Acetylcysteine is given by intravenous infusion or by mouth in the treatment of paracetamol poisioning. If given intravenously: 150mg/kg of acetylcysteine in 200mL of glucose 5 % is given initially over 15 minutes, followed by infusion of 50mg/kg in 500mL of glucose 5 % over the next 4 hours and then 100mg/kg in one litre of glucose 5 % over the next 16 hours. Sodium chloride 0.9 % may be used where glucose 5 % is unsuitable. Burns, Children with inhalation injury who ere treated with aerolised heparin 5000 units alternating with 3mL of 20 % acetylcysteine solution, inhaled every 2 hours for the 1st 7 days after injury, appeared to have significantly reduced mortality and reintubation rates compared with historical control.
Hypersensitivity to acetylcysteine or any component of the formulation.
Hypersensitivity reactions have been reported in patients receiving acetylcysteine, including bronchospasm, angioedema, rashes and pruritus: hypotension or occassionally hypertension, may occur.
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