How much and how often should you use the product?
Carvedilol tablets are taken orally. Consult your doctor on the right dosage or number of tablets you should be taking each day based on your age, overall health, and medical conditions.
Dosage for heart function problems following heart attack:
- The recommended starting dosage is 6.25 mg taken twice per day.
- It can be increased after 3 to 10 days to 12.5 mg taken twice per day.
- It can be increased up to 25 mg taken twice per day.
- You’ll be kept on a lower dosage if you can’t tolerate higher dosages.
Dosage for high blood pressure:
- The recommended starting dose is 6.25 mg taken twice per day.
- It can be increased after 7 to 14 days based on your blood pressure level one hour after your dose.
- Your dosage can be first increased to 12.5 mg taken twice per day. It can be increased again to 25 mg taken twice per day.
- The total dosage shouldn’t go over 50 mg per day.
Dosage for heart failure:
- The recommended starting dosage is 3.125 mg taken twice per day for two weeks.
- It can be increased to 6.25 mg, 12.5 mg, and 25 mg taken twice per day over two-week intervals.
- When you first start the medication and during dosage increases, you might feel dizzy and lightheaded within the first hour of taking your dose. During this time, you shouldn’t drive or do any similar activities that require alertness.
Mechanism of Action
Carvedilol inhibits exercise-induced tachycardia through its inhibition of beta adrenoceptors.
Carvedilol’s action on alpha-1 adrenergic receptors relaxes smooth muscle in vasculature, leading to reduced peripheral vascular resistance and an overall reduction in blood pressure. At higher doses, calcium channel blocking and antioxidant activity can also be seen. The antioxidant activity of carvedilol prevents oxidation of low-density lipoprotein and its uptake into coronary circulation.