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Losartan + Hydrochlorothiazide Tablets 100mg/25mg (Ekosart Plus Sandoz) – 30

Generic Name: Losartan + Hydrochlorothiazide

Brand Name: Ekosart Plus Sandoz

Dosage Strength:

Each tablet contains:

  • 100mg of losartan potassium
  • 25mg of hydrochlorothiazide
Dosage Form: Tablet

Indication: Losartan/HCTZ is indicated for the treatment of essential hypertension in patients whose blood pressure is not adequately controlled on losartan or hydrochlorothiazide alone.

Disclaimer: The contents of this site are for information purposes only and should not be construed as a substitute for professional medical advice. For diagnosis, treatment and prescription, consult your physician and other healthcare providers. Carefully read all product labels and packaging prior to use.

Where to buy

Generic Losartan Hydrochloride Tablets

Losartan is an angiotensin receptor blocker (ARB), a drug that relaxes blood vessels so that blood can flow more easily. Losartan is used to treat high blood pressure (hypertension) and to help protect kidneys from damage brought about by diabetes. Losartan can also be used to reduce the risk of strokes in patients that have high blood pressure and an enlarged heart. Managing high blood pressure helps prevent strokes, heart attacks, and kidney problems.

Hydrochlorothiazide, on the other hand, is a thiazide diuretic (water pill) that is used to prevent your body from absorbing and retaining too much salt. It is used to inhibit the kidneys’ ability to retain water while lowering the body’s blood pressure.

What is in the losartan and hydrochlorothiazide tablet?

Each tablet contains:

  • 100mg of losartan potassium
  • 25mg of hydrochlorothiazide

What are the losartan with hydrochlorothiazide tablets used for?

The losartan potassium tablets can be used to prevent the following:

  • Heart attack
  • Kidney disease
  • Stroke

How much and how often should you use the product?

Losartan hydrochlorothiazide tablets are taken orally. Your doctor will inform you of the right dosage or number of tablets you should be taking each day based on your age, overall health, and medical conditions.

Swallow the tablet whole with a glass of water, with or without food. Only take one dose at a time.

Hypertension: Losartan and hydrochlorothiazide is not for use as initial therapy, but in patients whose blood pressure is not adequately controlled by losartan potassium or hydrochlorothiazide alone. Dose titration with the individual components (losartan and hydrochlorothiazide) is recommended. When clinically appropriate, direct change from monotherapy to the fixed combination may be considered in patients whose blood pressure is not adequately controlled. The usual maintenance dose is one tablet of losartan 50mg/HCTZ 12.5mg, the dosage may be increased to a maximum of 2 tablets daily of losartan 50mg/HCTZ 12.5mg or one tablet of losartan 100mg/HCTZ 12mg once daily. The maximum dose is one tablet of losartan 100mg/HCTZ 25mg once daily.

In general, the antihypertensive effect is attained within three to four weeks after initiation of therapy.

Use in patients with renal impairment and hemodialysis patients: No initial dosage adjustment is necessary in patients with moderate renal impairment (i.e., creatinine clearance 30-50mL/ min). Losartan and hydrochlorothiazide tablets must not be used in patients with severe renal impairment (i.e., creatinine clearance < 30mL/min).

Use in patients with intravascular volume depletion: Volume and/or sodium depletion should be corrected prior to administration of Losartan/HCTZ tablets.

Use in the elderly: Dosage adjustment is not usually necessary for the elderly.

Use in children and adolescents (< 18 years): There is no experience in children and adolescents. Therefore, losartan hydrochlorothiazide should not be administered to children and adolescents.

Mechanism of Action

Losartan reversibly and competitively prevents angiotensin II from binding to the AT1 receptor in tissues such as the vascular smooth muscle and the adrenal gland.

Hydrochlorothiazide is a thiazide diuretic and interferes with the renal tubular mechanism of electrolyte reabsorption. Thiazides increase the secretion of sodium and chloride.

Before using this medication notify your doctor if you have or are:

  • Allergic to any food or syrup or substance
  • Pregnant or are planning to become pregnant or are nursing a baby
  • Dehydration
  • Kidney problems
  • Liver problems
  • Severe diarrhea or vomiting

Below are the possible side effects that you may experience from taking losartan hydrochlorothiazide tablets. These side effects are possible but do not always occur. If you experience any of these side effects, stop taking the product and immediately consult with your doctor.

  • Upper respiratory infection
  • Nasal congestion
  • Back pain
  • Chest pain
  • Fainting
  • Irregular heartbeat or palpitations
  • Muscle weakness
  • Unusual changes in the amount of urine output
  • Vomiting
  • Breathing difficulties
  • Itching
  • Loss of consciousness
  • Rash
  • Severe dizziness
  • Swelling of the face, tongue, or throat

Generic losartan hydrochlorothiazide tablets are available in all The Generics Pharmacy branches nationwide at a very affordable price.

Recommended Drug - Cardiovascular System - Hypertension Medicines
Recommended Drug - Cardiovascular System - HypertensionMedicines

How much and how often should you use the product?

Losartan hydrochlorothiazide tablets are taken orally. Your doctor will inform you of the right dosage or number of tablets you should be taking each day based on your age, overall health, and medical conditions.

Swallow the tablet whole with a glass of water, with or without food. Only take one dose at a time.

Hypertension: Losartan and hydrochlorothiazide is not for use as initial therapy, but in patients whose blood pressure is not adequately controlled by losartan potassium or hydrochlorothiazide alone. Dose titration with the individual components (losartan and hydrochlorothiazide) is recommended. When clinically appropriate, direct change from monotherapy to the fixed combination may be considered in patients whose blood pressure is not adequately controlled. The usual maintenance dose is one tablet of losartan 50mg/HCTZ 12.5mg, the dosage may be increased to a maximum of 2 tablets daily of losartan 50mg/HCTZ 12.5mg or one tablet of losartan 100mg/HCTZ 12mg once daily. The maximum dose is one tablet of losartan 100mg/HCTZ 25mg once daily.

In general, the antihypertensive effect is attained within three to four weeks after initiation of therapy.

Use in patients with renal impairment and hemodialysis patients: No initial dosage adjustment is necessary in patients with moderate renal impairment (i.e., creatinine clearance 30-50mL/ min). Losartan and hydrochlorothiazide tablets must not be used in patients with severe renal impairment (i.e., creatinine clearance < 30mL/min).

Use in patients with intravascular volume depletion: Volume and/or sodium depletion should be corrected prior to administration of Losartan/HCTZ tablets.

Use in the elderly: Dosage adjustment is not usually necessary for the elderly.

Use in children and adolescents (< 18 years): There is no experience in children and adolescents. Therefore, losartan hydrochlorothiazide should not be administered to children and adolescents.

Mechanism of Action

Losartan reversibly and competitively prevents angiotensin II from binding to the AT1 receptor in tissues such as the vascular smooth muscle and the adrenal gland.

Hydrochlorothiazide is a thiazide diuretic and interferes with the renal tubular mechanism of electrolyte reabsorption. Thiazides increase the secretion of sodium and chloride.

Before using this medication notify your doctor if you have or are:

  • Allergic to any food or syrup or substance
  • Pregnant or are planning to become pregnant or are nursing a baby
  • Dehydration
  • Kidney problems
  • Liver problems
  • Severe diarrhea or vomiting

Below are the possible side effects that you may experience from taking losartan hydrochlorothiazide tablets. These side effects are possible but do not always occur. If you experience any of these side effects, stop taking the product and immediately consult with your doctor.

  • Upper respiratory infection
  • Nasal congestion
  • Back pain
  • Chest pain
  • Fainting
  • Irregular heartbeat or palpitations
  • Muscle weakness
  • Unusual changes in the amount of urine output
  • Vomiting
  • Breathing difficulties
  • Itching
  • Loss of consciousness
  • Rash
  • Severe dizziness
  • Swelling of the face, tongue, or throat

Generic losartan hydrochlorothiazide tablets are available in all The Generics Pharmacy branches nationwide at a very affordable price.

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