How much and how often should you use the product?
Losartan hydrochlorothiazide tablets are taken orally. Your doctor will inform you of the right dosage or number of tablets you should be taking each day based on your age, overall health, and medical conditions.
Swallow the tablet whole with a glass of water, with or without food. Only take one dose at a time.
Hypertension: Losartan and hydrochlorothiazide is not for use as initial therapy, but in patients whose blood pressure is not adequately controlled by losartan potassium or hydrochlorothiazide alone. Dose titration with the individual components (losartan and hydrochlorothiazide) is recommended. When clinically appropriate, direct change from monotherapy to the fixed combination may be considered in patients whose blood pressure is not adequately controlled. The usual maintenance dose is one tablet of losartan 50mg/HCTZ 12.5mg, the dosage may be increased to a maximum of 2 tablets daily of losartan 50mg/HCTZ 12.5mg or one tablet of losartan 100mg/HCTZ 12mg once daily. The maximum dose is one tablet of losartan 100mg/HCTZ 25mg once daily.
In general, the antihypertensive effect is attained within three to four weeks after initiation of therapy.
Use in patients with renal impairment and hemodialysis patients: No initial dosage adjustment is necessary in patients with moderate renal impairment (i.e., creatinine clearance 30-50mL/ min). Losartan and hydrochlorothiazide tablets must not be used in patients with severe renal impairment (i.e., creatinine clearance < 30mL/min).
Use in patients with intravascular volume depletion: Volume and/or sodium depletion should be corrected prior to administration of Losartan/HCTZ tablets.
Use in the elderly: Dosage adjustment is not usually necessary for the elderly.
Use in children and adolescents (< 18 years): There is no experience in children and adolescents. Therefore, losartan hydrochlorothiazide should not be administered to children and adolescents.
Mechanism of Action
Losartan reversibly and competitively prevents angiotensin II from binding to the AT1 receptor in tissues such as the vascular smooth muscle and the adrenal gland.
Hydrochlorothiazide is a thiazide diuretic and interferes with the renal tubular mechanism of electrolyte reabsorption. Thiazides increase the secretion of sodium and chloride.