Metformin Tab 850mg (GLUCOTIN)-100
It is given by mouth in the treatment of non-insulin dependent (type 2 diabetes mellitus).
Dosage and Administration:
Given by mouth in the treatment of non insulin-dependent diabetes mellitus in an initial dosage of 500mg two or three times a day or 850mg once or twice a day with or after meals, gradually increased if necessary to a maximum of 2 or 3 g daily. Or as prescribed by the physician.
Diabetic coma, ketoacidosis, impaired renal function, chronic liver disease, cardiac failure, recent myocardial infarction, alcoholism, tissue hypoxia lactic acidosis, severe infections, trauma , surgery; dehydration.
Metformin should not be used in insulin dependent diabetes mellitus, Metformin should not be used in patients with heart failure, myocardial infarction, dehydration, acute or chronic alcoholism, or any other condition likely to predispose to lactic acidosis.
Metformin causes gastro-intestinal adverse effects with anorexia, nausea, and vomiting; absorption of various substances including Vitamin B12 may be impaired. Patients may experience a metallic taste and there may be weight loss. Hypoglycemia is less of a problem with metformin than with the sulphonylureas. Lactic acidosis, sometimes fatal, has occured but to a lesser extent than with phenformin and it is generally accepted that the lactic acidosis usually occured in patients whose condition contra-indicated the use of metformin particularly those with renal impairment.
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