QUADMAX Rifampicin + Isoniazid + Pyrazinamide + Ethambutol Film Coated Tablet
150 mg / 75 mg / 400 mg / 275 mg
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DESCRIPTION
QUADMAX is a fixed dose combination antituberculosis medication containing Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol. It is used in the intensive phase of tuberculosis (TB) treatment. This combination works by killing Mycobacterium tuberculosis through multiple mechanisms, improving treatment effectiveness, reducing bacterial resistance, and simplifying dosing to enhance patient compliance.
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USES
• Treatment of pulmonary tuberculosis (TB)
• Treatment of extrapulmonary tuberculosis, as prescribed
• Intensive phase therapy of drug susceptible tuberculosis
• Part of combination therapy under a standardized TB treatment program
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DOSAGE
Use strictly as directed by a physician or TB treatment program.
• Adults:
Dosage is weight based and determined by a healthcare professional according to national or WHO TB treatment guidelines
• Tablets are usually taken once daily, preferably on an empty stomach
⚠️ It is essential to complete the full course of therapy, even if symptoms improve, to prevent drug resistance.
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PRECAUTIONS
• Strict medical supervision required throughout treatment
• Monitor liver function tests, as several components may cause hepatotoxicity
• Rifampicin may discolor urine, sweat, saliva, and tears (harmless but permanent staining of contact lenses may occur)
• Use with caution in patients with liver disease, gout, optic neuritis, or renal impairment
• Numerous drug interactions occur, especially with rifampicin (e.g., oral contraceptives, anticoagulants, antiretrovirals)
• Report immediately any symptoms such as:
o Yellowing of skin or eyes
o Severe nausea or vomiting
o Visual disturbances
o Numbness or tingling
• Pyridoxine (Vitamin B6) supplementation may be prescribed alongside isoniazid
• Consult a healthcare professional before use during pregnancy or breastfeeding
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SIDE EFFECTS
• Gastrointestinal discomfort (nausea, vomiting, abdominal pain)
• Elevated liver enzymes or hepatitis
• Orange red discoloration of body fluids (rifampicin)
• Peripheral neuropathy (isoniazid)
• Joint pain or hyperuricemia (pyrazinamide)
• Visual disturbances, optic neuritis (ethambutol)
• Skin rash or itching
• Rare but serious: liver failure, severe hypersensitivity reactions
Seek immediate medical attention if severe or persistent adverse effects occur.
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STORAGE
• Store below 30 °C
• Protect from moisture and direct sunlight
• Keep tablets in the original packaging
• Keep out of reach of children
• Do not use beyond the expiration date