DEPOTRUST (Medroxyprogesterone Injection) 50 mg / 3 mL
(Progestin Hormonal Injection)
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DESCRIPTION
DepoTrust contains Medroxyprogesterone Acetate (MPA), a synthetic progestin hormone.
It is used in injectable form to provide long-acting hormonal effects on the reproductive system, including suppression of ovulation and regulation of abnormal uterine bleeding or contraception (depending on formulation and dosing schedule).
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USES
DepoTrust injection may be used for:
• Hormonal contraception (in some dosing regimens/forms)
• Irregular or abnormal uterine bleeding
• Endometriosis-related symptoms
• Amenorrhea (absence of menstruation)
• Hormone replacement therapy support (in selected cases)
• Management of certain gynecological hormone-related conditions
Note: The exact use depends on the prescribed dose schedule determined by a healthcare provider.
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DOSAGE AND ADMINISTRATION
• Given as an intramuscular (IM) or sometimes subcutaneous injection by a healthcare professional
• The 50 mg / 3 mL vial may be used for short-acting or cycle-based hormonal therapy depending on indication
Typical general guidance (varies by condition):
• For hormonal regulation: 50–150 mg per injection at intervals prescribed (e.g., every 1–3 months or cyclic use)
• Must be administered only under medical supervision
• Injection site is usually buttock or upper arm (IM route)
⚠️ Dosage and frequency must be strictly individualized by a physician.
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PRECAUTIONS
Use with caution in patients with:
• History of blood clots (DVT/PE)
• Liver disease
• Breast cancer or hormone-sensitive tumors
• Unexplained vaginal bleeding
• Depression or mood disorders
• Diabetes or hypertension
• Osteoporosis risk (long-term use may reduce bone density)
Additional precautions:
• May delay return to fertility after discontinuation
• Not recommended during pregnancy
• Does not protect against HIV or other sexually transmitted infections
• Long-term use requires periodic medical evaluation
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SIDE EFFECTS
Common:
• Irregular menstrual bleeding or spotting
• Weight gain
• Headache
• Bloating
• Breast tenderness
• Mood changes or irritability
Serious (seek medical attention):
• Severe abdominal or pelvic pain
• Signs of blood clot (leg swelling, chest pain, shortness of breath)
• Severe depression or mood changes
• Vision changes
• Allergic reactions (rash, swelling, difficulty breathing)
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STORAGE
• Store at room temperature (15–30°C)
• Protect from light and heat
• Do not freeze
• Keep vial in original packaging until use
• Store out of reach of children
• Do not use if solution is discolored or expired